In recently examining why we could not reproduce certain in vitro data involving the attenuation of signals originating in distal basal dendrites, we discovered that pronounced fluctuation in the diameter measurements in the j4 morphology files, lead to a bottlenecking effect that significantly reduces voltage transfer between distal sites and the cell body. Here is a brief manuscript summarizing our findings. We have made available smoothed versions of the morphology file in NEURON simulator .HOC files.

contact Bardia Behabadi with any questions/comments at behabadiATusc.edu